Initial Severity of Schizophrenia and Efficacy of Antipsychotics...
ImportanceAntipsychotic drugs constitute the mainstay in the treatment of schizophrenia, and their efficacy is well established in hundreds of randomized clinical trials. However, it is not known...
View ArticleAntipsychotic Treatment and Functional Connectivity of the Striatum in...
ImportancePrevious evidence has implicated corticostriatal abnormalities in the pathophysiology of psychosis. Although the striatum is the primary target of all efficacious antipsychotics, the...
View ArticleTelemedicine-Based Collaborative Care for Posttraumatic Stress Disorder A...
ImportancePosttraumatic stress disorder (PTSD) is prevalent, persistent, and disabling. Although psychotherapy and pharmacotherapy have proven efficacious in randomized clinical trials, geographic...
View ArticleCombined Rasagiline and Antidepressant Use in Parkinson Disease in the ADAGIO...
ImportanceDepression, cognitive impairment, and other nonmotor symptoms (NMSs) are common early in Parkinson disease (PD) and may be in part due to disease-related dopamine deficiency. Many patients...
View ArticleThe Norepinephrine Transporter in Attention-Deficit/Hyperactivity Disorder...
ImportanceAttention-deficit/hyperactivity disorder (ADHD) research has long focused on the dopaminergic system’s contribution to pathogenesis, although the results have been inconclusive. However, a...
View ArticleEffect of Anti-inflammatory Treatment on Depression, Depressive Symptoms, and...
ImportanceSeveral studies have reported antidepressant effects of anti-inflammatory treatment; however, the results have been conflicting and detrimental adverse effects may contraindicate the use of...
View ArticlePlacebo Response in Antipsychotic Clinical Trials A Meta-analysis
ImportanceBecause increasing placebo response rates decrease drug-placebo differences and increase the number of failed trials, it is imperative to determine what is causing this trend.ObjectivesTo...
View ArticleCardiometabolic Risk in Patients With First-Episode Schizophrenia Spectrum...
ImportanceThe fact that individuals with schizophrenia have high cardiovascular morbidity and mortality is well established. However, risk status and moderators or mediators in the earliest stages of...
View ArticlePrefrontal Cortical Dendritic Spine Pathology in Schizophrenia and Bipolar...
ImportancePrior studies have demonstrated reduced dendritic spine density in the dorsolateral prefrontal cortex (DLPFC) in schizophrenia. However, it remains unclear how generalizable this finding is...
View ArticleBenzodiazepine Use in the United States
ImportanceAlthough concern exists regarding the rate of benzodiazepine use, especially long-term use by older adults, little information is available concerning patterns of benzodiazepine use in the...
View ArticleWhy Are Benzodiazepines Not Yet Controlled Substances?
In this issue of JAMA Psychiatry, Olfson et al report a very comprehensive study of the use of benzodiazepines in the United States. This study confirmed what has been found in several other countries,...
View ArticleTelemedicine-Based Collaborative Care for Posttraumatic Stress Disorder A...
ImportancePosttraumatic stress disorder (PTSD) is prevalent, persistent, and disabling. Although psychotherapy and pharmacotherapy have proven efficacious in randomized clinical trials, geographic...
View ArticleInitial Severity of Schizophrenia and Efficacy of Antipsychotics...
ImportanceAntipsychotic drugs constitute the mainstay in the treatment of schizophrenia, and their efficacy is well established in hundreds of randomized clinical trials. However, it is not known...
View ArticleAntipsychotic Treatment and Functional Connectivity of the Striatum in...
ImportancePrevious evidence has implicated corticostriatal abnormalities in the pathophysiology of psychosis. Although the striatum is the primary target of all efficacious antipsychotics, the...
View ArticleEfficacy and Safety of Lisdexamfetamine for Treatment of Adults With Moderate...
ImportanceBinge-eating disorder (BED), a public health problem associated with psychopathological symptoms and obesity and possibly with metabolic syndrome, lacks approved pharmacotherapies.ObjectiveTo...
View ArticleA Multimodal Analysis of Antipsychotic Effects on Brain Structure and...
ImportanceRecent data suggest that treatment with antipsychotics is associated with reductions in cortical gray matter in patients with schizophrenia. These findings have led to concerns about the...
View ArticleChanges in Drug Coverage Generosity and Untreated Serious Mental Illness...
ImportanceMore than 1 in 5 disabled people with dual Medicare-Medicaid enrollment have schizophrenia or a bipolar disorder (ie, a serious mental illness). The effect of their transition from Medicaid...
View ArticleEmergency Department Visits by Children and Adolescents for Antipsychotic...
The per capita number of outpatient visits in which an antipsychotic drug was supplied or prescribed increased approximately 660% among children and 380% among adolescents between the mid-1990s and the...
View ArticleRetaining Part D’s Comprehensive Coverage of Antidepressants Not a Silver...
This Viewpoint briefly reviews evidence on the range of antidepressant choices needed for depression treatment, examines current antidepressant use patterns in Part D, and assesses how the proposed...
View ArticleVenlafaxine Extended-Release for Depression Following Spinal Cord Injury A...
ImportanceDepression is prevalent and associated with negative outcomes in individuals with spinal cord injury (SCI). Antidepressants are used routinely to treat depression, yet no placebo-controlled...
View Article
